Molecule profile
Semax is a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) studied in models of neurotrophic signaling and gene transcription. An analogue of an ACTH fragment extended by Pro-Gly-Pro, it is described in the preclinical publications below. The Velia Labs reference is restricted to laboratory work; published models do not establish indications for using the supplied product.
Research use only. The Semax sold by Velia Labs is a reference chemical intended exclusively for laboratory research (in vitro or experimental models). It is neither a medicine nor a dietary supplement: it is not intended for human or animal consumption, and nothing on this page constitutes medical advice or an administration protocol.
Semax derives from fragment 4-7 of ACTH (adrenocorticotropic hormone), to which a Pro-Gly-Pro tail gives increased resistance to peptidases. Unlike native ACTH, it has no significant effect on the hypothalamic-pituitary-adrenal axis: its research interest lies in the central nervous system, where it modulates neurotrophin expression.
Work by Dolotov and colleagues established that Semax rapidly increases expression and phosphorylation along the BDNF/trkB pathway in the rodent hippocampus, and raises BDNF protein levels in the basal forebrain. Further transcriptomic studies showed activation of the genes encoding neurotrophins (including NGF, nerve growth factor) and their receptors after experimental ischaemic injury. This trophic modulation sits at the centre of current research protocols: synaptic plasticity, neuroprotection in cerebral ischaemia models, and working memory in behavioural models.
A genome-wide analysis (Medvedeva et al., 2014) additionally showed that Semax affects the expression of genes tied to the immune and vascular systems in focal cerebral ischaemia — which makes it a tool for studying the interaction between neuroinflammation and post-ischaemic recovery. For laboratories it is therefore a reference peptide for exploring neurotrophic cascades without confounding the results with corticotropic hormonal activity.
The publications below are the public scientific basis for Semax. They report regulated preclinical and clinical research — they do not define any use for the research products Velia Labs sells.
Dolotov OV, Karpenko EA, Inozemtseva LS, et al. — Brain Research, 2006
The key study: increased BDNF expression and phosphorylation of the trkB receptor in the rat hippocampus following administration of the peptide.
Read on PubMed (PMID: 16996037)Dmitrieva VG, Povarova OV, Skvortsova VI, et al. — Cellular and Molecular Neurobiology, 2010
Transcriptional activation of the neurotrophins (NGF, BDNF) and their receptors in an experimental cerebral ischaemia model.
Read on PubMed (PMID: 19633950)Medvedeva EV, Dmitrieva VG, Povarova OV, et al. — BMC Genomics, 2014
Genome-wide transcriptomic analysis showing the impact of Semax on immune and vascular genes in focal ischaemia.
Read on PubMed (PMID: 24661604)Compare chemical reference, batch identity, analytical methods and available results with the requirements established by your laboratory. A publication about Semax does not certify a supplied batch or replace its certificate of analysis.
Both peptides were developed by the same Russian groups, but their targets differ: Semax mainly modulates the neurotrophin pathways (BDNF, NGF), while Selank, an analogue of tuftsin, acts primarily on GABAergic neurotransmission and on cytokines. In research they are often studied as complements to one another.
No. Semax is registered as a medicine in some post-Soviet countries, but it is approved by neither the EMA nor the FDA. The product sold by Velia Labs is a research reagent with no therapeutic purpose whatsoever.
Check the sequence, the identity, the analytical method, the lot number and the corresponding report. The Velia Labs product page distinguishes reference values from the actual status of the analyses available.
Cold (ideally -20 °C for long-term storage), protected from light and moisture, in its sealed vial. Once reconstituted, stability depends on the chosen solvent and the conditions of the protocol — follow your own laboratory’s good practice.
Check the formats, stock, technical data and analysis status currently shown on the product page. Shipping across France and Europe.
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