Molecule profile
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. An analogue of tuftsin extended by a Pro-Gly-Pro sequence, it is studied in models covering GABAergic neurotransmission and cytokine modulation. The Velia Labs listing is strictly for research; its product page shows stock, technical data and current documentation status.
Research use only. The Selank sold by Velia Labs is a reference chemical intended exclusively for laboratory research (in vitro or experimental models). It is neither a medicine nor a dietary supplement: it is not intended for human or animal consumption, and nothing on this page constitutes medical advice or an administration protocol.
Selank inherits its immunomodulatory properties from tuftsin (Thr-Lys-Pro-Arg), to which the Pro-Gly-Pro tail adds greater stability against peptidases. Its research profile is organised around two main axes: GABAergic neurotransmission and the regulation of inflammatory cytokines.
On the GABAergic side, the reference study by Volkova et al. (2016, Frontiers in Pharmacology) showed that Selank alters the expression of dozens of genes involved in GABAergic neurotransmission — GABA-A receptor subunits, transporters, and GABA synthesis enzymes — within an hour of administration in rodents. Rather than direct benzodiazepine-style binding, this appears to be allosteric modulation of the system, which is what makes research models of selank and anxiety interesting: an experimental anxiolytic profile without the sedation or tolerance characteristic of benzodiazepines in those models.
On the immune side, Russian preclinical and clinical work has reported a normalisation of the Th1/Th2 cytokine balance and suppression of IL-6 gene expression in experimental stress and anxiety models. Selank also influences enkephalin metabolism by inhibiting the enzymes that degrade them. This dual signature — GABA plus cytokines such as IL-6 — makes it a strong tool for studying the interface between the nervous and immune systems.
The publications below are the public scientific basis for Selank. They report regulated preclinical and clinical research — they do not define any use for the research products Velia Labs sells.
Volkova A, Shadrina M, Kolomin T, et al. — Frontiers in Pharmacology, 2016
A genomic study: altered expression of 45 of 84 genes linked to GABAergic neurotransmission one hour after administration in rats.
Read on PubMed (PMID: 26924987)Kasian A, Kolomin T, Andreeva L, et al. — Behavioural Neurology, 2017
Selank compared with diazepam in the unpredictable chronic mild stress model: reduction in behavioural markers of anxiety.
Read on PubMed (PMID: 28280289)Kolik LG, Nadorova AV, Antipova TA, et al. — Bulletin of Experimental Biology and Medicine, 2019
Protection against ethanol-induced memory deficits in the rodent model, associated with regulation of hippocampal and prefrontal BDNF.
Read on PubMed (PMID: 31625062)In animal models of stress and anxiety, Selank reduces behavioural markers of anxiety and modulates the expression of GABAergic genes. Russian clinical trials have compared it with benzodiazepines with a favourable tolerability profile. These are research data: the Velia Labs product is not intended for therapeutic use.
The same Russian academic origin, but distinct mechanisms: Selank (a tuftsin analogue) acts mainly on GABAergic neurotransmission and on cytokines such as IL-6, while Semax (an ACTH(4-7) analogue) modulates the BDNF and NGF neurotrophins. In research the two are frequently studied in comparison or in combination.
Check the sequence (Thr-Lys-Pro-Arg-Pro-Gly-Pro), the identity, the analytical method, the lot number and the corresponding report. The Velia Labs product page distinguishes reference values from the actual status of the analyses available.
Selank is registered as a medicine in some post-Soviet countries, but it is approved by neither the EMA nor the FDA. The product sold by Velia Labs is a research reagent with no therapeutic purpose.
Cold (ideally -20 °C for long-term storage), protected from light and moisture, in its sealed vial. Once reconstituted, stability depends on the solvent and the conditions of the protocol — follow your own laboratory’s good practice.
Check the formats, stock, technical data and analysis status currently shown on the product page. Shipping across France and Europe.
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